@deepika , I checked out the anxocare drug... It's not a certified drug for anxiety or depression, just used indiscriminately... So, I won't recommend it. But, if, only if ,the collar and other methods fail, I will suggest a proper, approved, antidepressant. (Obviously to be checked by a vet and also a psychiatrist). In the meantime, you change all cage set up, no nesting materials should be there. Don't worry, we're with you. All the best.